Uniform CR Bound: Implement ation Issues And Applications


We apply a uniform Cramer-Rao (CR) bound [l] to study the bias-variance trade-offs in single photon emission computed tomography (SPECT) image reconstruction. The uniform CR bound is used to specify achievable and unachievable regions in the bias-variance trade-off plane. The image reconstruction algorithms considered in this paper are: 1) Space alternating generalized EM and 2) penalized weighted least-squares.


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